![Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2- and c-FLIP-overexpressing breast carcinoma cells Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2- and c-FLIP-overexpressing breast carcinoma cells](https://www.spandidos-publications.com/article_images/or/33/3/OR-33-03-1395-g00.jpg)
Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2- and c-FLIP-overexpressing breast carcinoma cells
![ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells | Leukemia ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells | Leukemia](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fsj.leu.2404719/MediaObjects/41375_2007_Article_BF2404719_Fig1_HTML.jpg)
ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells | Leukemia
![ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells | Cell Death & Disease ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells | Cell Death & Disease](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fcddis.2012.163/MediaObjects/41419_2012_Article_BFcddis2012163_Fig1_HTML.jpg)
ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells | Cell Death & Disease
![Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B | Cell Death & Disease Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B | Cell Death & Disease](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fcddis.2012.109/MediaObjects/41419_2012_Article_BFcddis2012109_Fig4_HTML.jpg)
Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B | Cell Death & Disease
![The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized - ScienceDirect The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1535610806002911-gr2.jpg)
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized - ScienceDirect
![ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells [PeerJ] ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells [PeerJ]](https://dfzljdn9uc3pi.cloudfront.net/2013/144/1/fig-8-2x.jpg)
ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells [PeerJ]
![ABT-737 affected cell growth, induced apoptosis and modulated Bcl-2... | Download Scientific Diagram ABT-737 affected cell growth, induced apoptosis and modulated Bcl-2... | Download Scientific Diagram](https://www.researchgate.net/publication/282125922/figure/fig1/AS:294694619365376@1447272080520/ABT-737-affected-cell-growth-induced-apoptosis-and-modulated-Bcl-2-family-protein.png)
ABT-737 affected cell growth, induced apoptosis and modulated Bcl-2... | Download Scientific Diagram
![The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized - ScienceDirect The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S1535610806002911-gr4.jpg)
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized - ScienceDirect
![Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B | Cell Death & Disease Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B | Cell Death & Disease](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fcddis.2012.109/MediaObjects/41419_2012_Article_BFcddis2012109_Fig1_HTML.jpg)
Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B | Cell Death & Disease
![Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2- and c-FLIP-overexpressing breast carcinoma cells Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2- and c-FLIP-overexpressing breast carcinoma cells](https://www.spandidos-publications.com/article_images/or/33/3/OR-33-03-1395-g03.jpg)
Combined treatment with ABT-737 and VX-680 induces apoptosis in Bcl-2- and c-FLIP-overexpressing breast carcinoma cells
![Chemical structure and mode of action of the BH3 mimetic ABT-737 in... | Download Scientific Diagram Chemical structure and mode of action of the BH3 mimetic ABT-737 in... | Download Scientific Diagram](https://www.researchgate.net/publication/321370742/figure/fig1/AS:941419820773387@1601463384335/Chemical-structure-and-mode-of-action-of-the-BH3-mimetic-ABT-737-in-combination-with-the.gif)
Chemical structure and mode of action of the BH3 mimetic ABT-737 in... | Download Scientific Diagram
![Schematic summary of the effects of ABT-737 on human oral cancer cells.... | Download Scientific Diagram Schematic summary of the effects of ABT-737 on human oral cancer cells.... | Download Scientific Diagram](https://www.researchgate.net/publication/282769796/figure/fig8/AS:487110261121027@1493147544839/Schematic-summary-of-the-effects-of-ABT-737-on-human-oral-cancer-cells-The-Bim.png)
Schematic summary of the effects of ABT-737 on human oral cancer cells.... | Download Scientific Diagram
![ABT-737 is a Selective and BH3 Mimetic Bcl-2, Bcl-xL and Bcl-w Inhibitor - Network of Cancer Research ABT-737 is a Selective and BH3 Mimetic Bcl-2, Bcl-xL and Bcl-w Inhibitor - Network of Cancer Research](https://www.cancer-research-network.com/wp-content/uploads/ABT-737-is-a-Selective-and-BH3-Mimetic-Bcl-2-Bcl-xL-and-Bcl-w-Inhibitor-2021-12-28.jpg)
ABT-737 is a Selective and BH3 Mimetic Bcl-2, Bcl-xL and Bcl-w Inhibitor - Network of Cancer Research
![Cancers | Free Full-Text | The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death Cancers | Free Full-Text | The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death](https://pub.mdpi-res.com/cancers/cancers-12-00108/article_deploy/html/images/cancers-12-00108-ag.png?1581005300)
Cancers | Free Full-Text | The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death
![ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL | Journal of Experimental & Clinical Cancer Research | Full Text ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2F1756-9966-31-102/MediaObjects/13046_2012_Article_632_Fig5_HTML.jpg)
ABT-737 reverses the acquired radioresistance of breast cancer cells by targeting Bcl-2 and Bcl-xL | Journal of Experimental & Clinical Cancer Research | Full Text
![Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins | Oncogene Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins | Oncogene](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fonc.2008.259/MediaObjects/41388_2008_Article_BFonc2008259_Fig1_HTML.jpg)
Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins | Oncogene
![Cancers | Free Full-Text | The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death Cancers | Free Full-Text | The Application of Arsenic Trioxide in Ameliorating ABT-737 Target Therapy on Uterine Cervical Cancer Cells through Unique Pathways in Cell Death](https://www.mdpi.com/cancers/cancers-12-00108/article_deploy/html/images/cancers-12-00108-g007.png)